Shopping Cart » Quantitative PAR ELISA   » 3D Assays   » Stem Cell Assays   » Cell Invasion   » PathClear® BME   » PARP   » CometAssay®  Home » Angiogenesis & Cell Differentiation Angiogenesis & Cell Differentiation Cultrex® 3D Culture 96 Well BME Cell Proliferation Assay Recent studies indicate that the composition of the extracellular environment influences cellular responses to apoptosis inducing agents1, 2 implicating a role for extracellular proteins in influencing both toxicity and drug resistance. As a result, this environment must be mimicked during the course of cell-based studies to provide the most accurate translation to animal models The Cultrex® 3-D Culture Cell Proliferation Assays provide a more physiologically relevant assessment when using cell models in the screening process for compounds that influence toxicity. These assays offer a flexible, standardized, high-throughput format for quantitating the degree to which pharmacological compounds influence toxicity or tumorigenicity within in vivo-like environments. The Cultrex® 3-D Culture Cell Proliferation Assay has been adapted to multiple formats so that cell proliferation may be evaluated within different extracellular matrices; BME, Laminin I, and Collagen I.   Applications: Tests for the inhibition of proliferation and formation of 3D structures in a BME matrix.   Components: Part # Component Size   3445-005-01 3D Culture Matrix 5 ml   3445-096-02 Cell Proliferation Reagent 3 ml   3445-096-03 3D Culture Stripwells 96 well 2 plates   Storage: Components are stored at -20ºC and at room temperature.   References: 1. Aoudjit F, Vuori K. (2001) Integrin signaling inhibits paclitaxel-induced apoptosis in breast cancer cells. Oncogene 20:4995-5004. 2. Hodkinson PS, Elliott T, Wong WS, Rintoul RC, Mackinnon AC, Haslett C, T Sethi. (2006) ECM overrides DNA damage-induced cell cycle arrest and apoptosis in small-cell lung cancer cells through ß1 integrin-dependent activation of PI3-kinase. Cell Death and Differentiation 13, 1776-88.   Top   Ordering Information Catalog #: Price: 3445-096-K Cultrex 3D Culture BME Cell Proliferation Assay Kit, 96 Tests $240.00 Trevigen Products are now available for ordering through - AND - Download Protocols Related Products Cultrex 3D Culture 96 Well Collagen I Cell Proliferation Assay Cultrex 3D Culture 96 Well Laminin I Cell Proliferation Assay Cultrex 3D Culture Cell Proliferation Assay Core Kit Cultrex 3D Culture Matrix Cell Harvesting Kit Cultrex 3D Culture Matrix Rat Collagen I Cultrex 3D Culture Matrix Laminin I Cultrex 3D Culture Matrix BME TREVIGEN INC. :: 8405 HELGERMAN CT. :: GAITHERSBURG, MD 20877 1.800.TREVIGEN :: 1.800.873.8443 :: (FAX) 1.301.560.4973 :: INFO@TREVIGEN.COM :: SITE MAP