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Cultrex® Bovine Fibronectin NZHD*

Fibronectin is a 440 kDa, soluble disulfide linked dimer composed of two 220 kDa independent globular peptide chains. It is an extracellular matrix protein that is found abundantly in blood, connective tissues, and provisional matrices associated with malignant transformation of migratory cells, and has demonstrated functions in both cell-cell and cell-matrix interactions. Fibronectin functions either as a general cell adhesion molecule or as a modulator in binding between cell surfaces and the extracellular matrix by means of a central cell-binding domain, RGD (Arg-Gly-Asp).

Applications:
  • Cell adhesion
  • medium additive
  •  
    Preparation: Provided in Tris, pH 7.0, 2M Urea at a concentration of 1 mg/ml.
     
    Performance Testing: Functionally tested for its ability to promote attachment of HT-1080 cells.
     
    Source: Bovine plasma from New Zealand**.
     
    Storage: Store at -20°C or -80°C in a manual defrost freezer. Avoid freeze-thaw cycles.
     
    References: Vaheri A, Mosher DF. High molecular weight, cell surface-associated glycoprotein (fibronectin) lost in malignant transformation. Biochim Biophys Acta. 1978 Sep 18; 516(1):1-25.

    Edelman GM. Cell adhesion molecules, Science. 1983 Feb 4; 219(4584):450-7.

    **New Zealand was granted neglible BSE risk disease status at the 75th General Session of the World Organization for Animal Health (OIE) (http://www.oie.int/eng/info/en_statesb.htm), and GBR I status by the European Food Safety Authority (http://ec.europa.eu/food/fs/sc/ssc/out292_en.pdf). No cases of BSE have been reported in New Zealand since monitoring began in 1989 (http://www.oie.int/eng/info/en_esbcarte.htm).

    *NZHD = New Zealand Herd Derived
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    Ordering Information
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    Catalog #: Price:

    3416-001-01
    Cultrex Fibronectin,
    1 mg
    $140.00
    Add to Cart

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