Shopping Cart » DIVAATM     » Cell Invasion     » PathClear® BME     » PARP     » CometAssayTM     » HT 8-oxo-dG ELISA  Home » Angiogenesis & Cell Differentiation Angiogenesis & Cell Differentiation Cultrex® 3D Culture Matrix™ Rat Collagen I 3-D Culture is an innovative approach to modeling the morphological effects of early oncogenesis on glandular epithelial cells. When healthy, these cells exhibit a structured, polarized morphology that is critical for cellular formation and function. During carcinoma development, cell cycle controls associated with cellular development, proliferation and death are lost, and as a result, these ascinaric structures are disrupted. In effect, the morphology of these structures can be used as a measure to study factors in early carcinoma development. Trevigen has developed the 3D Culture Matrix™ product line to provide reagents specifically produced for and qualified in 3-D culture studies. Applications: The 3-D Culture Matrix™ Rat Collagen I may be used as a gel on which to grow cells or a media additive alone or in concert with other basement membrane components to study cellular growth and differentiation in three dimensions in vitro.   Preparation: 3-D Culture Matrix™ Rat Collagen I is provided in 20 mM acetic acid without phenol red at a concentration of 5 mg/ml.   Source: Rat tail tendons.   Storage: Product is stable for a minimum of 3 months if stored at 4°C. Do not Freeze.   References: JS: Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods, 2003 pp. 256-268. Chen, S., r. Revoltella, S. Papini, M. Michelini, W. Fitzgerald, J. Zimmerberg, and L. Margolis. 2003. Multilineage differentiation of rhesus monkey embyonic stem cells in three-dimensional culture systems. Stem Cells. 21:281-295. Top   Ordering Information Catalog #: Price: 3447-020-01 3D Collagen I Rat Tail, 100 mg $165.00 Trevigen Products are now available for ordering through Download Protocol Related Products Cultrex Basement Membrane Extract Cultrex 3D Culture Matrix BME Cultrex 3D Culture Matrix Laminin I Cultrex 3D Culture Matrix Cell Harvesting Kit Cultrex 3D Culture 96 Well Collagen I Cell Proliferation Assay Cultrex 3D Culture 96 Well Laminin I Cell Proliferation Assay Cultrex 3D Culture Cell Proliferation Assay Core Kit Cultrex 3D Culture 96 Well BME Cell Proliferation Assay TREVIGEN INC. :: 8405 HELGERMAN CT. :: GAITHERSBURG, MD 20877 1.800.TREVIGEN :: 1.800.873.8443 :: (FAX) 1.301.560.4973 :: INFO@TREVIGEN.COM