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Cultrex® Human BME PathClear®

Basement membranes are continuous sheets of specialized extracellular matrix that form an interface between endothelial, epithelial, muscle, or neuronal cells and their adjacent stroma. Basement membranes are degraded and regenerated during development and wound repair. They not only support cells and cell layers, but they also play an essential role in tissue organization that affects cell adhesion, migration, proliferation, and differentiation. Basement membranes provide major barriers to invasion by metastatic tumor cells. Cultrex® Human Basement Membrane Extract (BME) is a soluble form of basement membrane purified from human placenta.

Applications: Promotion and maintenance of an undifferentiated phenotype, or differentiation of precursors, including stem cells, into primary epithelial cells, endothelial cells and smooth muscle cells. It has been employed in cell attachment assays, neurite outgrowth assays, and tumor cell invasion assays.
 
Source: Human Placenta
 
Concentration: 1 mg/ml
 
Storage: Store at -80°C in a manual defrost freezer. Avoid repeated freeze-thaw cycles.
 
Related Articles: Albini, A., Y. Iwamoto, H. Kleinman, G. Martin, S. Aaronson, J. Kozlowski, and R. McEwan. 1987. A rapid in vitro assay for quantitating the invasive potential of tumor cells. Cancer Res. 47:3239-3245.
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Ordering Information
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Catalog #: Price:

3415-001-02
Cultrex® Human BME PathClear®,
1 ml
$175.00
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