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Anti-8-oxo-dG Monoclonal Antibody (Clone 2E2)

DNA damage caused by oxidative radicals is associated with aging, inflammation, carcinogenesis, Parkinson’s and Alzheimer’s diseases. When exposed to oxidative radicals, 8-hydroxy-2’-deoxyguanosine (8-oxo-dG) is formed and can serve as a sensitive indicator of physiological and environmental damage to DNA. This mouse monoclonal antibody is provided to enable the detection of 8-oxo-dG by ELISA, or by immunocytochemistry.

Immunogen: 8-oxo-dG-conjugated-KLH
 
Source: Mouse
 
Specificity: This mouse monoclonal antibody specifically binds to 8-hydroxy-2’- deoxyguanosine within DNA in H2O2-treated cells
 
Isotype: IgG2b
 
Preparation: This antibody is provided as purified immunoglobulin from mouse ascites in 1X PBS containing 0.01% sodium azide.
 
Applications:
  • ELISA
  • Immunocytochemistry
  • Immunohistochemistry
  •  
    Storage: Freeze in working aliquots at -20°C in a manual defrost freezer to avoid repeated freeze-thawings.
     
    References: 1 Soultanakis RP, Melamede RJ, Bespalov IA, Wallace SS, Beckman KB, Ames BN, Taatjes DJ, Janssen-Heininger YMW. (2000) Flourescence detection of 8-oxoguanine in nuclear and mitochondrial DNA of cultured cells using a recombinant Fab and confocal scanning laser microscopy. Free Rad Biol Med 28:987-998.
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    Ordering Information
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    Catalog #: Price:

    4354-MC-50
    Anti-8-oxo-dG Monoclonal Antibody,
    50 µl
    $415.00
    Add to Cart

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