3-Aminobenzamide
3-aminobenzamide is the PARP inhibitor provided with Trevigen's PARP Inhibition Assay Kit (Cat# 4669-96-K) at 200 mM. 3-aminobenzamide attenuates tissue injury following transient cerebral ischemia.
4-Amino-1,8-naphthalimide
4-Amino-1,8-naphthalimide is a potent inhibitor of poly(ADP-ribose) polymer (PARP) and reduces ischemia-reperfusion injury in the heart and skeletal muscle. It is 1000-fold more potent that 3-aminobenzamide and exhibits mixed-type inhibition with respect to the sub-strate, NAD+, at micromolar concentrations. This inhibitor, which has been analyzed at a concentration of 20 µM, is provided at a convenient concentration for subsequent serial dilution and use with Trevigen's PARP Inhibition Assay Kit (Cat# 4669-96-K).
6(5H)-Phenanthridinone
6(5H)-Phenanthridinone strongly inhibits poly(ADP-ribose) polymerase (PARP) and displays immunosuppressive activity. It is a mixed-type inhibitor that acts on both the enzyme and enzyme-NAD+ complex at site(s) distinct from the NAD+-binding site to attenuate the fall in NAD and ATP and, consequently, improve cell survival. It also inhibits concanavalin A-induced lymphocyte proliferation at micromolar concentrations. This inhibitor, which has been analyzed in the range of 0.18-0.39 µM, is provided at a convenient concentration for subsequent serial dilution and use with Trevigen's PARP Inhibition Assay Kit (Cat# 4669-96-K).
Benzamide
Benzamide is the most potent poly(ADP-ribose) polymerase (PARP) inhibitor in the family of benzamides. It acts as a neuroprotectant since it inhibits PARP, an enzyme activated by nitric oxide. Benzamide is twice as active than its commonly used counterpart, 3-aminobenzamide in delaying or suppressing PARP activation. It is able to prevent nuclear fragmentation and apoptotic-body formation without affecting DNA fragmentation during apoptosis. This PARP inhibitor, which has been analyzed in the range of 100 to 500 µM, is provided at a convenient concentration for subsequent serial dilution and use with Trevigen's PARP Inhibition Assay Kit (Cat# 4669-96-K).
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Ordering Information
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Catalog #:
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Price:
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4667-50-09
4-Amino-1;8-naphthalimide (800 µM),
100 µl |
$110.00
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4667-50-11
Benzamide (8 mM),
100 µl |
$110.00
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4667-50-10
6(5H)-Phenanthridinone (160 µM),
100 µl |
$110.00
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